Guanidine hydrochloride AR 99.5% [50-01-1] Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase. A powerful chaotropic agent useful for denaturation and subsequent protein refolding. This strong denaturant can dissolve insoluble or denatured proteins such as inclusion bodies. This can be used as a first step in refolding proteins or enzymes to their active form.
Melting point: 180-185 ° C (lit.)
Density: 1.18 g / ml at 25 ° C (lit.)
refractive index: n20 / D 1.465
storage temperature: Store at RT.
solubility: H2O: 6 M, transparent, colorless
color: white to slightly yellow
PH: 4.5-5.5 (100 g / l, H2O, 20 ℃)
Solubility in water: 2280 g / L (20 ºC)
λ: 260 nm Amax: 0.040
λ: 280 nm Amax: 0.025
Labeling of hazardous chemicals and mixtures that are part of the Globally Harmonized System of Classification and Labeling of Chemicals (GHS). The pictograms recommended by GHS have the shape of a square set on the top. They should contain a black symbol on a white background with a red border.
Priority rules to be observed in connection with the labeling of a substance:
– the skull and crossbones, the exclamation mark pictogram should not be added.
– corrosive effect, the exclamation mark pictogram should not be added if it concerns eye or skin irritation.
– health hazard determining respiratory sensitization, the exclamation mark pictogram should not be added if it concerns skin sensitization or irritation to eyes or skin.
Source: GHS pictograms